Publications

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2016

Netrin-1 regulated distribution of UNC5B and DCC in live cells revealed by TICCS

Gopal AA, Rappaz B, Rouger V, Martyn IB, Dahlberg PD, Meland RJ, Beamish IV, Kennedy TE, Wiseman PW.

Biophysical Journal

[ Link ]
Lipid Microdomains in Synapse Formation

Madwar C, Gopalakrishnan G, Lennox RB

ACS Chemical Neuroscience

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Rapid Mechanically Controlled Rewiring of Neuronal Circuits

Magdesian MH, Lopez-Ayon GM, Mori M, Boudreau D, Goulet-Hanssens A, Sanz R, Miyahara Y, Barrett CJ, Fournier AE, De Koninck Y, Grutter P.

Journal of Neuroscience

[ Link ]

2015

Formula for Unsilencing Plasticity: Spike with GABA Neuron

Kesner P, Gobert D, Ruthazer ES

Neuron

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Integration of Shallow Gradients of Shh and Netrin-1 Guides Commissural Axons

Sloan T, Qasaimeh MA, Juncker D, Yam P, Charron F

PLoS Biology

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Properties of human CNS neurons in a glia-‐depleted (isolated) culture system

Leong SY, Kaplan A, Wang LC, Almazan G, Fournier AE, Antel J.

J. Neurosci Methods

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Extrinsic and intrinsic regulation of axon regeneration at a crossroads

Kaplan A, Ong Tone S, Fournier AE

Front Mol Neurosci

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Interfacing Living Cells and Spherically Supported Bilayer Lipid Membranes

Madwar C, Gopalakrishnan G, Lennox RB

Langmuir

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Spatial intensity distribution analysis reveals abnormal oligomerization of proteins in single cells

Godin AG, Rappaz B, Potvin-Trottier L, Kennedy TE, DeKoninck Y, Wiseman PW

Biophys. J.

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Non-‐invasive measurement of choroidal volume change and ocular rigidity through automated segmentation of high-‐ speed OCT imaging

Beaton L, Mazzaferri J, Lalonde F, H M, Descovich D, Lesk MR, Costantino S

Journal of Biomedical Optics

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Substrate-‐Bound Protein Gradients to Study Haptotaxis

Ricoult SG, Kennedy TE, Juncker D

Frontiers in Bioengineering and Biotechnology

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Complete loss of netrin-‐1 results in embryonic lethality and severe axon guidance defects without increased neural cell death

Bin JM, Han D, Lai Wing Sun K, Croteau LP, Dumontier E, Cloutier JF, Kania A, Kennedy TE

Cell Reports

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Scanning Electrochemical Microscopy Forced Convection Method for Substrate Kinetic Determination: Application to Life Cell Imaging of Human Cancer

Kuss S, Trinh D, Mauzeroll J

Analytical Chemistry

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2014

Switching responses: spatial and temporal regulators of axon guidance

Kaplan A, Kent C, Charron F, Fournier AE

Molecular Neurobiology

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Collapsin response mediator protein 4 regulates growth cone dynamics through the actin and microtubule cytoskeleton

Khazaei MR, Girouard MP, Alchini R, Ong Tone S, Shimada T, Bechstedt S, Cowan M, Guillet D, Wiseman PW, Brouhard G, Cloutier JF, Fournier AE

J Biol Chem

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CRMP4 regulates growth cone dynamics through coordinated regulation of the actin and microtubule cytoskeleton

Khazaei M, Girouard M-‐P, Alchini R, Ong Tone S, Shimada T, Bechstedt S, Cowan M, Guillet D, Wiseman PW

J. Biol. Chem.

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Tuning cell-surface affinity to direct cell specific responses to patterned proteins

Ricoult SG, Thompson-Steckel G, Correia JP, Kennedy TE, Juncker DJ

Biomaterials

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Neurite outgrowth and growth cone collapse assays to assess neuronal responses to extracellular cues

Kaplan A, Sanz R, Ferraro GB, Alchini R, Fournier AE

Methods Mol. Biol.

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Maintaining and Modifying Connections: Roles for Axon Guidance Cues in the Mature Nervous System

Thompson-Steckel G, Kennedy TE

Neuropsychopharmacology

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Ordered, Random, Monotonic, and Non-‐ monotonic Digital Nanodot Gradients

Ongo G, Ricoult SG, Kennedy TE, Juncker D

PLoS One

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A Disk-Shaped Amperometric Enzymatic Biosensor for In Vivo Detection of D-Serine

Polcari D, Kwan A, Van Horn M, Danis L, Pollegioni L, Ruthazer ES, Mauzeroll J

Analytical Chemistry

[ Download ]
Composite Living Fibers for Creating Tissue Constructs Using Textile Techniques

Akbari M, Tamayol A, L V, Annabi N, Najafabadi AH, Khademhosseini A, Juncker D.

Advanced Functional Materials

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Microfluidic probes for use in life sciences and medicine

Qasaimeh MA, Ricoult SG, Juncker D

Lab Chip

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Laser-assisted adsorption by photobleaching

Bélisle JM, Mazzaferri J, Costantino S

Methods Cell Biol

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Humidified Microcontact Printing of Proteins: Universal Patterning of Proteins on Both Low and High Energy Surfaces

Ricoult SG, Sanati Nezhad A, Knapp-‐Mohammady M, Kennedy TE, Juncker D

Langmuir

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Microfluidic Direct Writer with Integrated Declogging Mechanism for Fabricating Cell-Laden Hydrogel Constructs

Ghorbanian S, Qasaimeh MA, Akbari M, Tamayol A, Juncker D

Biomedical Microdevices

[ Download ] [ Link ]
Effect of Head Group Size on Photoswitching Applications of Azobenzene Disperse-‐Red 1 Analogues

Goulet-Hanssens A, Corkery TC, Priimagi A, Barrett CJ

J. Materials Chemistry

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A long Stokes shift red fluorescent Ca2+ indicator protein for two-‐photon and ratiometric imaging

Wu J, Abdelfattah AS, Miraucourt LS, Kutsarova E, Ruangkittisakul A, Zhou H, Ballanyi K, Wicks G, Drobizhev M, Rebane A, Ruthazer ES, Campbell RE

Nature Communications

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Rapid Hebbian axonal remodeling mediated by visual stimulation

Munz M, Gobert D, Schohl A, Poquérusse J, Podgorski K, Spratt P, Ruthazer ES

Science

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IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth

Sanz R, Fournier AE

J Biol Chem

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2013

Lipidome and proteome map of myelin membranes

Gopalakrishnan G, Awasthi A, Belkaid W, De Faria O, Liazoghli D, Colman D, Dhaunchak A

Journal of Neuroscience Research

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D-serine as a gliotransmitter and its roles in brain development and disease

Van Horn MR, Sild M, Ruthazer ES

Frontiers in Cellular Neurosci

[ Download ] [ Link ]
Large Dynamic Range Digital Nanodot Gradients of Biomolecules Made by Low-Cost Nanocontact Printing for Cell Haptotaxis

Ricoult SG, Pla-Roca M, Safavieh R, Lopez-Ayon M, Grütter P, Kennedy TE, Juncker D

Small

[ Link ]
Switching Responses: Spatial and Temporal Regulators of Axon Guidance

Kaplan A, Kent C, Charron F, Fournier AE

Molecular Neurobiology

[ Link ]
Microfluidic probes for use in life sciences and medicine

Qasaimeh MA, Ricoult SG, Juncker D

Lab Chip

[ Download ] [ Link ]
Analysis of Pulsatile Retinal Movements by Spectral-Domain Low-Coherence Interferometry: Influence of Age and Glaucoma on the Pulse Wave

Dion C, Singh K, Ozaki T, Lesk MR and Costantino S

PLoS One

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Measuring ligand–receptor binding kinetics and dynamics using k-space image correlation spectroscopy

Brandao H, Sangji H, Pandzic E, Bechstedt S, Brouhard GJ, Wiseman PW

Methods

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DCC expression by neurons regulates synaptic plasticity in the adult brain

Horn KE, Glasgow SD, Gobert D, Bull SJ, Luk T, Girgis J, Tremblay ME, McEachern D, Bouchard JF, Haber M, Hamel E, Krimpenfort P, Murai KK, Berns A, Doucet G, Chapman CA, Ruthazer ES, Kennedy TE

Cell Reports

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Photo-Control of Biological Systems with Azobenzene Polymers

Goulet-Hanssens A, Barrett CJ

Journal of Polymer Science Part A

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Netrin-1 Promotes Excitatory Synaptogenesis between Cortical Neurons by Initiating Synapse Assembly

Goldman JS, Ashour MA, Magdesian MH, Tritsch NX, Harris SN, Christofi N , Chemali R, Stern YE, Thompson-Steckel G, Gris P, Glasgow SD, Grutter P, Bouchard JF, Ruthazer ES, Stellwagen D, Kennedy TE

J. Neurosci.

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Cellular response to micropatterned growth promoting and inhibitory substrates

Belkaid W, Thostrup P, Yam PT, Juzwik CA, Ruthazer ES, Dhaunchak AS, Colman DR

BMC Biotechnology

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2012

Substrate Micropatterning as a New in Vitro Cell Culture System to Study Myelination

Liazoghli D, Roth AD, Thostrup P, Colman DR

ACS Chemical Neuroscience

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Ligand-induced clustering of EGF receptors: A quantitative study by fluorescence image moment analysis

Sergeev M, Swift JL, Godin AG, Wiseman PW

Biophysical Chemistry

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A CANDLE for deeper in vivo insight

Coupé P, Munz M, Manjon JV, Ruthazer ES, Collins DL

Medical Image Analysis

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GABA Expression and Regulation by Sensory Experience in the Developing Visual System

Miraucourt LS, Santos da Silva J, Burgos K, Li JL, Abe H, Ruthazer ES, Cline HT

PLoS One

[ Download ]
Generation of MicroIsland Cultures using Microcontact Printing to Pattern Protein Substrates

Ricoult SG, Goldman JS, Stellwagen D, Juncker D and Kennedy TE

J Neuroscience Methods

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Engineered cell culture substrates for axon guidance: moving beyond proof of concept

Roy J, Kennedy T, Costantino S

LAB on a CHIP

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Retrograde and Wallerian Axonal Degeneration Occur Synchronously after Retinal Ganglion Cell Axotomy

R Kanamori A, Catrinescu MM, Belisle JM, Costantino S, Levin LA

American J Pathology

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High-content neurite development study using optically patterned substrates

Belisle JM, Levin LA, Costantino S

PLoS One

[ Download ]
Fabrication of Two-Dimensional Gradient Layer-by-Layer Films for Combinatorial Biosurface Studies

Sailer M, Barrett CJ

Macromolecules

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High-throughput cellular screening of engineered ECM based on combinatorial polyelectrolyte multilayer films

Sailer M, Lai Wing Sun K, Mermut O, Kennedy TE, Barrett CJ

Biomaterials

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Expression patterns of Ephs and ephrins throughout retinotectal development in Xenopus laevis

Higenell V, Han SM, Feldheim DA, Scalia F, Ruthazer ES

Dev. Neurobiol.

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Photoreversible surfaces to regulate cell adhesion

Goulet-Hanssens A, Lai Wing Sun, K, Kennedy TE, Barrett CJ

Biomacromolecules

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Atomic Force Microscopy Reveals Fundamental Differences in Axonal Resistance to Injury

Magdesian MH, Sanchez FS, Lopez Ayon GM, Thostrup P, Durisic N, Belkaid W, Liazoghli D, Grütter P, Colman DR

Biophys. J.

[ Download ] [ Link ]
14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing

Yam PT, Kent CB, Morin S, Farmer WT, Alchini R, Lepelletier L, Colman DR, Tessier-Lavigne M, Fournier AE, Charron F.

Neuron

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Listening to Npas4: a transcription factor is the prescription for restoring youthful plasticity in the mature brain

Van Horn MR, Ruthazer ES

J Physiol

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2011

Label-Free Visualization of Ultrastructural Features of Artificial Synapses via Cryo-EM

Gopalakrishnan G, Yam PT, Madwar C, Bostina M, Rouiller I, Colman DR, Lennox RB

ACS Chemical Neuroscience

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Midline Axon Guidance and Human Genetic Disorders

Izzi L and Charron F

Clinical Genetics

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Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation

Izzi L, Lévesque M, Morin S, Laniel D, Wilkes BC, Mille F, Krauss RS, McMahon AP, Allen BL, Charron F

Developmental Cell

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Expression patterns of Ephs and ephrins throughout retinotectal development in Xenopus laevis

Higenell V, Han SM, Feldheim DA, Scalia F, Ruthazer, ES

Developmental Neurobiology

[ Link ]
Radial Glia: Progenitor, Pathway and Partner

Sild M and Ruthazer ES

The Neuroscientist

[ Download ] [ Link ]
Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways

Balghi H, Robert R, Rappaz B, Zhang X, Wohlhuter-Haddad A, Evagelidis A, Luo Y, Goepp J, Ferraro P, Roméo P, Trebak M, Wiseman PW, Thomas DY, Hanrahan JW

FASEB J.

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Development of Single Retinofugal Axon Arbors in Normal and β2 Knockout Mice

Dhande OS, Hua EW, Guh E, Yeh J, Bhatt S, Zhang Y, Ruthazer ES, Feller MB, Crair MC

J Neurosci

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Morphological and functional characterization of cholinergic interneurons in the dorsal horn of the mouse spinal cord

Mesnage B, Gaillard S, Godin A, Rodeau JL, Hammer M, von Engelhardt J, Wiseman PW, De Koninck Y, Schlichter R, Cordero-Erausquin M

Journal of Comparative Neurology

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Dynamics of HIV budding site interactions with an ESCRT component visualized in live-cells

Baumgärtel V, Ivanchenko S, Dupont A, Sergeev M, Wiseman PW, Kräusslich HG, Bräuchle C, Müller B, Lamb DC

Nature Cell Biology

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Microfluidic quadrupole and floating concentration gradient

Qasaimeh MA, Gervais T, Juncker D

Nature Communication

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Activity-dependent transcription of BDNF enhances visual acuity during development

Schwartz N, Schohl A, Ruthazer ES

Neuron

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VEGF mediates commissural axon chemoattraction through its receptor Flk1

Ruiz de Almodovar CE, Fabre PJ, Knevels E, Coulon C, Segura I, Haddick PCG, Aerts L, Delattin N, Strasser G, Oh W-J, Lange C, Vinckier S, Haigh J, Fouquet C, Henderson C, Gu C, Alitalo K, Castellani V, Tessier-Lavigne M, Chedotal A, Charron F, Carmeliet P

Neuron

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Laser-Based Single-Axon Transection for High-Content Axon Injury and Regeneration Studies

Kunik D, Dion C, Ozaki T, Levin LA, Costantino S

PLoS One

[ Download ]
Quantitative analysis of receptor tyrosine kinase transactivation via direct dimerization and surface density measurements in single cells

Swift JL, Godin AG, Doré K, Freland L, Bouchard N, Nimmo CM, Sergeev M, De Koninck Y, Wiseman PW, Beaulieu JM

PNAS

[ Download ]
Revealing protein oligomerization and densities in situ using spatial intensity distribution analysis

Godin AG, Costantino S, Lorenzo LE, Swift JL, Sergeev M, Ribeiro-da-Silva A, De Koninck Y, Wiseman PW

PNAS

[ Download ]

2010

Neurodevelopmental effects of chronic exposure to elevated levels of pro-inflammatory cytokines in a developing visual system

Lee RH, Mills EA, Schwartz N, Bell MR, Deeg KE, Ruthazer ES

Neural Development

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CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of Stargazin

Opazo P, Labrecque S, Tigaret CM, Frouin A, Wiseman PW, De Koninck P, Choquet D

Neuron

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Isolation of Functional Presynaptic Complexes from CNS Neurons: A Cell-Free Preparation for the Study of Presynaptic Compartments In Vitro

Lucido AL, Gopalakrishnan G, Yam PT, Colman DR, Lennox RB

ACS Chemical Neuroscience

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Layers upon layers: MHC class I acts in the retina to influence thalamic segregation

Higenell V and Ruthazer ES

Neuron

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Lipid Bilayer Membrane- Triggered Presynaptic Vesicle Assembly

Gopalakrishnan G, Thostrup P, Rouiller I, Lucido AL, Belkaïd W, Colman DR, Lennox RB

ACS Chemical Neuroscience

[ Link ]
Integrated microfluidic probe station

Perrault CM, Qasaimeh MA, Brastaviceanu T, Anderson K, Kabakibo Y, Juncker D

Review of Scientific Instruments

[ Download ] [ Link ]
Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A

Joyal J-S, Sitaras N, Binet F, Zaniolo K, Stahl A, Rivera JC, Shao Z, Polosa A, Zhu T, Hamel D, Djavari M, Kunik D, Honore J-C, Picard E, Zabeida A, Varma D, Hickson G, Mancini J, Klagsbrun M, Costantino S, Beausejour C, Lachapelle P, Smith L, Chemtob S,

BLOOD

[ Download ] [ Link ]
Learning to See: Patterned visual activity and the development of visual function

Ruthazer ES and Aizenman CD

Trends in Neuroscience

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A Sensitive Period for Spike Timing-Dependent Plasticity in the Xenopus Retinotectal Projection

Tsui JJ, Schwartz N, Ruthazer, ES

Frontiers in Synaptic Neuroscience

[ Download ]
A proteome map of axoglial specializations isolated and purified from human central nervous system

Dhaunchak AS, Huang JK, De Faria Junior O, Roth AD, Pedraza L, Antel JP, Bar-Or A, Colman DR

Glia

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14-3-3 proteins regulate protein kinase a activity to modulate growth cone turning responses

Kent CB, Shimada T, Ferraro GB, Ritter B, Yam PT, McPherson PS, Charron F, Kennedy TE, Fournier AE

J Neurosci

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The Role of Interstitial Branching in the Development of Visual Corticocortical Connections: A Time-lapse and Fixed-tissue Analysis

Ruthazer ES, Bachleda AR, Olavarria, JF

Journal of Comparative Neurology

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Dissection and culture of commissural neurons from embryonic spinal cord

Langlois SD, Morin S, Yam PT, Charron F

Journal of Visualized Experiments

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Chamber and Microfluidic Probe for Microperfusion of Organotypic Brain Slices

Queval A, Ghattamaneni NR, Perrault CM, Gill R, Mirzaei M, McKinney RA, Juncker D

Lab on a Chip

[ Link ]

2009

Neural activity regulates synaptic function and dendritic structure in vivo through calcineurin/NFAT Signaling

Schwartz N, Schohl A, Ruthazer ES

Neuron

[ Link ]
Sonic hedgehog guides axons through a non-canonical, Src family kinase-dependent signaling pathway

Yam PT, Langlois SD, Morin S, Charron F

Neuron

[ Link ]
Mapping protein complexes in living cells from laser scanning confocal image sequences: the ccRICS method

Digman MA, Wiseman PW, Horwitz AR, Gratton E

Biophysical Journal

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N-cadherin prodomain cleavage regulates synapse formation in vivo

Latefi NS, Pedraza L, Schohl A, Li Z, Ruthazer ES

Developmental Neurobiology

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Rapid Assembly of Functional Presynaptic Boutons Triggered by Adhesive Contacts

Lucido AL, Sanchez FS, Thostrup P, Kwiatkowski AV, Leal-Oritz S, Gopalakrishnan G, Liazoghli D, Belkaid W, Lennox RB, Grutter P, Garner CG, Colman DR

J Neurosci

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Regulation of Radial Glial Motility by Visual Experience

Tremblay M, Fugère V, Tsui J, Schohl A, Tavakoli A, Travençolo BAN, Costa L, Ruthazer ES

J Neurosci

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The Microfluidic Probe: Operation and Use for Localized Surface Processing

Perrault CM, Qasaimeh MA, Juncker D

Journal of Visualized Experiments

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Supported Bilayers Formed from Different Phospholipids on Spherical Silica Substrates

Gopalakrishnan G, Rouiller I, Colman DR, Lennox RB

Langmuir

[ Link ]

2008

GAP-43 is key to mitotic spindle control and centrosome-based polarization in neurons

Mishra R, Gupta SK, Meiri KF, Fong Thostrup MP, Juncker D, Mani S

Cell Cycle

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Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1

Moore SW, Correia JP, Lai Wing Sun K, Pool M, Fournier AE, Kennedy TE.

Development

[ Download ]
Innate Immune-mediated Neuronal Injury Consequent to Loss of Astrocytes

Darlington P J; Podjaski C; Horn K; Costantino S; Blain M; Saikali P; Chen Z; Baker K; Newcombe J; Freedman M; Wiseman P; Bar-Or A; Kennedy TE; Antel J

J Neuropathol Exp Neurol

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Semi-automated quantification of filopodial dynamics

Costantino S, Kent CB, Godin AG, Kennedy TE, Wiseman PW, Fournier AE

J Neurosci Methods

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NeuriteTracer: a novel ImageJ plugin for automated quantification of neurite outgrowth

Pool M, Thiemann J, Bar-Or A, Fournier AE

J Neurosci Methods

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Patterning protein concentration using laser-assisted adsorption by photobleaching, LAPAP

Belisle JM, Correia J, Wiseman PW, Kennedy TE, Costantino S

Lab on a Chip

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Accurate measurements of protein interactions in cells via improved spatial image cross-correlation spectroscopy

Comeau JWD, Kolin DL, Wiseman PW

Molecular Biosystems

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On and Off Domains of Geniculate Afferents in Cat Primary Visual Cortex

Jin JZ, Weng C, Yeh CI, Gordon JA, Ruthazer ES, Stryker MP, Swadlow HA, Alonso JM

Nature Neuroscience

[ Download ]

2007

Dendritic Spine Viscoelasticity and Soft-Glassy Nature: Balancing Dynamic Remodeling with Structural Stability

Smith BA, Roy H, De Koninck P, Grutter P, De Koninck Y

Biophysical Journal

[ Link ]

2006

The role of neural activity in cortical axon branching

Uesaka N, Ruthazer ES, Yamamoto N

The Neuroscientist

[ Download ] [ Link ]

2005

Activity-Dependence of Cortical Axon Branch Formation: A Morphological and Electrophysiological Study Using Organotypic Slice Cultures

Uesaka N, Hirai S, Maruyama T, Ruthazer ES, Yamamoto N

J Neurosci

[ Link ]
You’re Perfect, Now Change – Redefining the Role of Developmental Plasticity

Ruthazer ES

Neuron

[ Link ]

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